Dental Newsletters

Clinical Articles Brought to You by Lexicomp and Dr. Richard L. Wynn

The purpose of this column is to keep professionals informed of recent reports regarding drugs and other events which may influence dental treatment. These reports will be gleaned from scientific journals, screened for dissemination, and presented on a timely basis and with great accuracy.

It is hoped the dental professional will reap significant benefit from this information, and it will contribute to superior patient care.

National Institute on Drug Abuse Study

Date: 
08/01/2014

Volkow, N.D.; Baler, R.D.; Compton, W.M.; Weiss, S.R.B. “Adverse health effects of marijuana use.” N Engl J Med 2014; 370:2219-2227.

The study’s authors are from the National Institute on Drug Abuse, National Institutes of Health, in Bethesda, Maryland.

Tetrahydrocannabinol, or THC, is the primary active ingredient in marijuana. The following is a list of clinical conditions for which marijuana has evidence of some effectiveness:

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Azithromycin and Risk of Cardiac Events - An Updated View

Date: 
07/01/2014

By R.L. Wynn

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Blood Pressure Drugs Associated With Troubling Postural Hypotension and Fall Risk in Older Adults

Date: 
06/01/2014

By R.L. Wynn

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Study shows no advantage to treating outpatients with Vicodin over Tylenol #3

Date: 
05/01/2014

Hydrocodone/acetaminophen provides no better pain relief and no better side effect profile compared to codeine/acetaminophen in treating acute pain at emergency department discharge

 By R.L. Wynn

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New studies examine links between antibiotics dental professionals use and cardiac issues

Date: 
04/01/2014

Azithromycin and levofloxacin may be associated with development of serious arrhythmias or sudden death in certain populations

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Is antibiotic prophylaxis before dental procedures the right approach?

Date: 
03/01/2014

More definitive studies required to identify appropriate candidates for antimicrobial prophylaxis in dental practice beyond valvular heart disease.

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The Association between Periodontal Disease and Cardiovascular Inflammation: Two New Reports

Date: 
01/01/2014

The link between oral health and systemic health is an area of growing interest. Two recent reports describe the relationship between periodontal inflammation and vascular inflammation.

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Important Update on Drugs and Other Risk Factors Associated With Osteonecrosis of the Jaw

Date: 
11/01/2013

Many cases of antiresorptive agent-induced osteonecrosis of the jawbone (ARONJ) have been associated with invasive dental procedures such as a tooth extraction. ARONJ cases have also been reported spontaneously or in patients who wear dentures or have other minor mucosal irritation sites (Hellstein, 2011). The bisphosphonate group of drugs has been associated with a risk of osteonecrosis of the jawbone (ONJ) for the past 10 years; it has been commonly termed BRONJ for bisphosphonate related ONJ.

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Opioid Prescribing by Dentists

Date: 
10/01/2013

Examination of the first report

Denisco, R.C., et al. "Prevention of prescription opioid abuse; the role of the dentist." JADA 2011; 142(7):800-809.

Background medical information in the Denisco report:

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Dental Surgery Post-op Pain Is Treated More Effectively With Ibuprofen-Acetaminophen Combination than Medications Containing Narcotics

Date: 
09/01/2013

This study was designed to compare the efficacy and tolerability of a novel single-tablet combination of ibuprofen and acetaminophen with that of an ibuprofen/codeine combination and an acetaminophen/codeine combination. The pain model was the third molar extraction model of postoperative acute pain.

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