Dental Newsletters

Clinical Articles Brought to You by Lexicomp and Dr. Richard L. Wynn

The purpose of this column is to keep professionals informed of recent reports regarding drugs and other events which may influence dental treatment. These reports will be gleaned from scientific journals, screened for dissemination, and presented on a timely basis and with great accuracy.

It is hoped the dental professional will reap significant benefit from this information, and it will contribute to superior patient care.

New Oral Contraceptives Increase Women's Cardiac Risk

Date: 
08/01/2013

Interactions with Antibiotics Commonly Used in Dentistry Unknown

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The Prescription Opioid Drug Abuse Crisis ? A Review for Your Awareness

Date: 
07/01/2013

The New England Journal of Medicine report of 2010

"A flood of opioids, a rising tide of deaths." Okie, S. Vol. 363(21): 1981-1985.

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The Prescription Opioid Drug Abuse Crisis ? A Review for Your Awareness

Date: 
07/01/2013

The New England Journal of Medicine report of 2010

"A flood of opioids, a rising tide of deaths." Okie, S. Vol. 363(21): 1981-1985.

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FDA Upholds Warnings About Increased Risk of Cardiovascular Deaths with Azithromycin (Zithromax or Zmax).

Date: 
06/01/2013

The Danish Study

The Danish study did not find an increased risk of cardiovascular death associated with azithromycin. The study results pointed to an increased risk among patients with a history of cardiovascular disease, and no significant differences were observed in comparison with patients who did not have that history.

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Osteonecrosis of the Jaw Bone Appearing In Patients Never Exposed To Bisphosphonates

Date: 
05/01/2013

The authors commented that osteonecrosis of the jawbone (ONJ) is not a new phenomenon and cases have been reported well before the use of bisphosphonates. ONJ has been reported in association with cancer chemotherapy and high-dose steroid use.

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I'll have the fish, with an aspirin on the side: Attacking inflammation with combined aspirin and omega-3s

Date: 
04/01/2013

Neutrophils are first to arrive at tissue sites undergoing an acute inflammatory response and play a protective role in host defense. But, excessive accumulation of these neutrophils in tissues leads to an increase in inflammatory response, prolongation of the signs of inflammation, and tissue damage. The family of fatty acid molecules called resolvins serve as a signal to our bodies use to start shutting down this type of inflammation. Resolvins are produced in the body from dietary omega-3 fatty acids.

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Over-the-counter analgesic use and potential hearing loss

Date: 
03/01/2013

The women's study showed that ibuprofen use and acetaminophen use were associated with increased risk of hearing loss, but aspirin use was not. Depending on the frequency of use, the relative risk of hearing loss from ibuprofen, with use more than 2 to 3 times per week, was up to 24% higher compared with use less than once per week. Depending on the frequency of use, the relative risk of hearing loss from acetaminophen, with use more than 2 to 3 times per week, was up to 21% higher compared with use less than once per week.

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Exploring potential predictors of bisphosphonate-associated osteonecrosis of the jawbone: serum N-telopeptide (NTX) and bone-specific alkaline phosphatase (BAP). Research from Memorial Sloan-Kettering Cancer Center, New York.

Date: 
02/01/2013

The N-telopeptide study was out of Memorial Sloan-Kettering Cancer Center, New York. The authors introduced the study by reviewing the use of bisphosphonates in decreasing the incidence of skeletal related events resulting from bone metastases in a variety of malignancies. The use of bisphosphonates in this context, however, is associated with ONJ. There is interest in developing biomarkers to identify patients at greatest risk of developing ONJ. However, no biomarkers have been validated in this capacity to date.

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Guideline update on antibiotic prophylaxis for joint replacement patients (December 2012)

Date: 
01/01/2013

There is insufficient evidence to recommend the routine use of antibiotics for patients with orthopaedic implants to prevent infections prior to having dental procedures.

Recommendation 1.

The practitioner might consider discontinuing the practice of routinely prescribing prophylactic antibiotics for patients with hip and knee prosthetic implants undergoing dental procedures.

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