Controlled Substances File

Help Meet Mandatory U.S. Compliance Requirements for Controlled Substances and Support Quality Assurance Programs

With ongoing increases in verification, monitoring, and reporting requirements for controlled substances, this data helps you meet mandatory compliance with U.S. regulations of controlled substances.

What It Does for Your Business

  • Helps your organization meet mandatory compliance requirements for prescribing, dispensing, and reporting controlled substances at the federal, state, and U.S. territory level
  • Assists multi-state organizations in reducing time spent manually researching and monitoring varying compliance requirements across different regions
  • Supports development by vendors and self-programmers of rules, applications, and reports to meet the needs of their users
  • Enhances prescribing, dispensing, and claims processing by allowing clinicians to use the data and developer applications to determine compliance with federal, state, and U.S. territory regulations
  • Supports quality assurance measures by providing the tools to create reports and develop analysis programs around controlled substances


  • Chain pharmacies operating in multiple states can reduce time spent manually researching and creating home-grown databases to monitor varying federal and state restrictions.
  • Pharmacists can double-check that submitted prescriptions comply with regulations and create retrospective quality assurance analysis programs.


Provides the tools to develop reports and create quality assurance programs around controlled substances.


Helps systems verify* clinicians are licensed to prescribe particular controlled substances. Additional indicators further support end-user prescribing applications and the development of quality assurance programs and reporting tools.

* When used with prescriber databases


Helps systems verify* clinicians are licensed to prescribe particular controlled substances.

* When used with prescriber databases


  • Saves time and helps streamline processes by providing access to Automation of Reports and Consolidated Orders System (ARCOS) reporting requirements with federal ARCOS indicator. The ARCOS indicator signals whether a particular NDC is ARCOS-reportable according to the DEA website.

What it provides

  • Federal, state, and U.S. territory level controlled substance schedules, PDMP, and ARCOS identified at the National Drug Code (NDC) level
  • Indicators, including:
    • E-prescribing
    • Refill limit
    • Duration limit
    • Quantity limit
    • Narcotic/non-narcotic designation
    • Narcotics Addiction DEA Number (NADEAN)
    • Prescription Drug Monitoring Program (PDMP)
    • Automation of Reports and Consolidated Orders System (ARCOS)

Why Medi-Span?

Overall Satisfaction


of customers are satisfied with the quality of Medi-Span data

Renewal Rate


of customers are likely to renew their Medi-Span data license



Hundreds of customers see 50% or greater increase in productivity with Medi-Span

See why more healthcare businesses are choosing Medi-Span for their drug data:

Reasons Customers Chose and Stay


  • Speed to Market

    Medi-Span implementation support helped save me one month in speed to market and about $10,000 in development costs.

    Keith Streckenbach, CEO
    HighFive Health

  • Fast Results

    Medi-Span, in my view, beats everyone else. It helps you find twice as many drug errors – errors that would lead to readmission - in half the amount of time.

    Keith Streckenbach, CEO
    HighFive Health

  • Competitive Advantage

    (Medi-Span) allows us to provide features that our competitors do not have.

    Senior developer from a healthcare software vendor

  • Valuable Resource

    As a claims processor, we rely on Medi-Span and its wealth of drug information to forecast and price claims for our clients. Medi-Span is the go-to (application) that is recognized across the industry for (manufacturer-provided) drug information. They have innovative tools and excellent customer service that will go above and beyond to provide the best available solution.

    Healthcare vendor systems analyst

  • Valuable Support

    Medi-Span implementation support helped save me one month in speed to market and about $10,000 in development costs.”

    Keith Streckenbach, CEO HighFive Health

  • Consistent Pricing Data

    It is the source for the benchmark prices consistently used in the PBM industry and the tool we use to hold PBMs accountable to their pricing promises to our employers.

    Insurance company senior actuarial consultant

  • Business Essential

    Business cannot survive without Medi-Span data.

    Fortune 500 PBM clinical pharmacist

  • Key Content

    Only reliable published resource for (manufacturer-provided) AWP. (Medi-Span proprietary) GPI is therapeutic classification system of choice. It is very enabling, as clinical management rules are easily articulated.

    Chief Pharmacy Officer from a PBM

  • Provides Confidence

    Even in an era where data abounds, there is a terrific amount of uncertainty. People want confidence that what they are seeing is (based on) real (manufacturer-provided information) – Medi-Span provides that confidence.

    Health plan executive

  • Unifying Data

    (Medi-Span) allows for consistency across the company, industry and clients.

    Manager from an insurance company

  • Timely and Relevant

    The Medi-Span database allows our system to have the latest and most current information available. It is especially needed for package information, interaction checking, and clinical printing.

    Executive from a healthcare software vendor

  • Strong Foundation

    This is a foundational piece that is used throughout the organization in many systems and is often used to connect data from multiple systems.

    Systems analyst from a top-grossing PBM


Who is Clinical Drug Information?

With the move to team-based care, conflicting data can lead to actual conflicts – from disparity in business decisions to confusion in communication. We research, validate, and synthesize content to show the right data to right people at the right time. With content developed in a consistent manner across all platforms and resources, your team receives aligned drug information no matter when or how they access it. This helps:

  • Improve communication
  • Reduce confusion
  • Enhance patient care

Learn more

Impacting thousands of healthcare organizations - see our story

Play Video
Resource Center

Resource Center

Learn about trending healthcare topics with RxPerts Academy – Knowledge for the Next Era of Healthcare

How can our award-winning drug data help you?

Learn more about Medi-Span